This chapter begins with the little magazines of the late nineteenth and early twentieth centuries and ends with contemporary online literary magazines, highlighting the radical changes that have taken place as print yielded to digital culture. Motivated by the contrarian personalities of their founding editors against commercial tastes, small-circulation periodicals prioritized aesthetic experimentation and established themselves as an avant-garde force in the arts. During the twentieth century, literary magazines would become institutionalized and relinquish their financial and intellectual independence. Their avant-garde status, once represented by a collectively upheld editorial persona, would become overshadowed by individual cults of personality around popular writers. Magazines’ social programs would become watered down, and instead writers would make themselves into social actors. The arrival of New Journalism in the 1960s and ’70s radically changed long-form journalism, rendering it more literary. The chapter ends with the contemporary literary magazine ecosystem, showing that what magazines have lost in materiality, they have gained in generic hybridity and global access.