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The Neuropathology of Dementia
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  • 163 b/w illus. 106 colour illus.
  • Page extent: 584 pages
  • Size: 276 x 219 mm
  • Weight: 2.038 kg

Library of Congress

  • Dewey number: 616.8/3
  • Dewey version: 21
  • LC Classification: RC521 .N475 2004
  • LC Subject headings:
    • Dementia--Pathogenesis
    • Postmortem changes
    • Autopsy
    • Dementia--etiology
    • Dementia--pathology

Library of Congress Record


 (ISBN-13: 9780521819152 | ISBN-10: 0521819156)

Unavailable - out of print February 2009


Completely rewritten and updated, this new edition is almost twice the size of its predecessor. It presents practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes three chapters on neuroimaging, molecular diagnostics, and transgenic models; two chapters on tauopathies under new authorship and a chapter under new authorship on synucleinopathies, including multiple system atrophy. First Edition Hb(1997): 0-521-43311-8


Preface; 1. Definition, clinical features and neuroanatomical basis of dementia Thomas J. Grabowski and Antonio R. Damasio; 2. Important anatomical landmarks in the brain in dementia James H. Morris and Margaret M. Esiri; 3. Practical approach to pathological diagnosis Margaret M. Esiri and James H. Morris; 4. Morphometric methods and dementia Michael C. Irizarry; 5. Safety precautions in laboratories involved with dementia diagnosis and research Jeanne E. Bell; 6. Molecular diagnosis of dementia Vivianna M. D. Van Deerlin; 7. Neuropathology of the aging brain Patrick R. Hof, Thierry Bussière and John H. Morrison; 8. Neuroimaging Alzheimer's disease Arthur W. Toga, Michael S. Mega and Paul M. Thompson; 9. Alzheimer's disease James H. Morris and Zs Nagy; 10. Down's syndrome and Alzheimer's disease D. M. A. Mann; 11. Sporadic tauopathies: Pick's disease, corticobasal degeneration, progressive supranuclear palsy and argyrophilic brain disease Dennis W. Dickson; 12. Hereditary tauopathies and idiopathic frontotemporal dementias Mark S. Forman, John Q. Trojanowski and Virginia M.-Y. Lee; 13. Vascular dementias James H. Morris, Hannu Kalimo and Matti Viitanen; 14. Familial and sporadic cerebral amyloid angiopathies associated with dementia and the BRI dementias Gordon T. Plant, Tamas Revesz, Janice L. Holton, Jorge Ghiso and Blas Frangione; 15. Parkinson's disease, dementia with Lewy bodies, multiple system atrophy and the spectrum of diseases with alpha-synuclein inclusions Benoit I. Giasson, Virginia M-Y. Lee and John Q. Trojanowski; 16. Huntington disease Jean Paul G. Vonsattel and Maxim Lianski; 17. Human prion diseases James W. Ironside and Mark W. Head; 18. Alcoholism and dementia Clive Harper and Richard Scolyer; 19. Hydrocephalus and dementia Margaret M. Esiri and G. Rosenberg; 20. Head injury and dementia C. Smith, J. A. R. Nicoll and D. I. Graham; 21. Infectious (and inflammatory) diseases causing dementia Harry V. Vinters; 22. Schizophrenia and dementia Paul J. Harrison; 23. Other diseases that cause dementia Margaret M. Esiri; 24. Transgenic mouse models of neurodegenerative disease David R. Borchelt, Joanna Jankowsky, Alena Savonenko, Gabriele Schilling, Jiou Wang and Guilian Xu; Appendix: Dementia brain banks; Index.


"...this is an excellent book and can be recommended particularly for psychiatry, neurology, and pathology residents, as well as practicing clinicians who frequently see dementia patients in their practices." Clinical Gerontologist

"The writing remains excellent, and the illustrations are now in color." Annals of Neurology, Barbara S. Crain, MD,PhD, Baltimore Maryland

"This authoritative and comprehensive book is one of those `must have' books and it will be invaluable for practising neuropathologists, as well as gerontologists, neurobiologists and psychiatrists working in the field of dementia. I must admit that I am delighted to have a copy of this book and have used it with more enthusiasm than I have ever thought possible." The Bulletin of the Royal College of Pathologists, Dr. Malee Fernando, Specialist Registrar in Neuropathology, Royal Hallamshire Hospital, Sheffield

"...a must for neuropathologists with an interest in dementia." ACNR, IAJ Larner, M Doran, Cognitive Function Clinic, WCNN, Liverpool

"There are many books on dementia, so an understandable response to news about yet another one is 'What's so special about this one?' The answer in this case is 'It has great perspective and is a joy to read.'" American Neurological Association, Barbara J. Crain

"This is a well-written reference textbook and is most appropriate for physicians and trainees in pathology, clinical neuroscience, and psychiatry with an interest in dementia. Neuroscientists engaged in neurodegenerative research will find it particularly useful as a one-stop resource of current literature."
Ravi Raghavan, Journal of Neurosurgery


Thomas J. Grabowski, Antonio R. Damasio, James H. Morris, Margaret M. Esiri, Michael C. Irizarry, Jeanne E. Bell, Vivianna M. D. Van Deerlin, Patrick R. Hof, Thierry Bussière, John H. Morrison, Arthur W. Toga, Michael S. Mega, Paul M. Thompson, Zs Nagy, D. M. A. Mann, Dennis W. Dickson, Mark S. Forman, John Q. Trojanowski, Virginia M.-Y. Lee, Hannu Kalimo, Matti Viitanen, Gordon T. Plant, Tamas Revesz, Janice L. Holton, Jorge Ghiso, Blas Frangione, Benoit I. Giasson, Jean Paul G. Vonsattel, Maxim Lianski, James W. Ironside, Mark W. Head, Clive Harper, Richard Scolyer, G. Rosenberg, C. Smith, J. A. R. Nicoll, D. I. Graham, Harry V. Vinters, Paul J. Harrison, David R. Borchelt, Joanna Jankowsky, Alena Savonenko, Gabriele Schilling, Jiou Wang, Guilian Xu

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