Hostname: page-component-848d4c4894-x5gtn Total loading time: 0 Render date: 2024-06-11T14:35:10.542Z Has data issue: false hasContentIssue false

Environmental intoxicants and their fundamental interactions

Published online by Cambridge University Press:  17 March 2009

J. Eisinger
Affiliation:
Bell Laboratories, Murray Hill, N. J. 07974
W. E. Blumberg
Affiliation:
Bell Laboratories, Murray Hill, N. J. 07974

Extract

The biological sciences are and should be responsive to the needs of medicine: thus the deficiency diseases (e.g. ben-ben and scurvy) stimulated the search for vitamins, just as contagious diseases fathered immunology and the study of antibiotics. It has been said that we live in the era of environmental disease, which suggests that an important fraction of human disease in technological societies is induced by environmental conditions, including some which are more commonly referred to as life styles. While this assessment requires further amplification (see below), it is clear that the sheer number and variety of potentially dangerous environmental agents has become so great that a better understanding of their fundamental interactions with the living system is clearly needed. As of the end of 1977, the American Chemical Society's Chemical Abstract Service contained over four million entities, and it is estimated that there are about 63000 chemicals in common usage. The toxicity of only a very small number of these has been investigated.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1978

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Andelman, D. A. (1977) Thai village finds tragedy on a road paved with lead. New York Times, 07 5.Google Scholar
Babish, J. G., Stoensand, G. S. & Lisk, D. J. (1978). Effect of diet on the hepatotoxicity of polybrominated biphenyls (Firemaster PB-6). Environ. Health. Perspect. 23, 133137.Google Scholar
Blumberg, W. E. (1978). Enzymic modification of environmental intoxicants: The role of Cytochrome P-450. Q. Rev. Biophys. 10, 481542.Google Scholar
Braudel, F. (1974). Capitalism and Material Life, 1400–1800. Fontana Publishing Co. pp. 3754.Google Scholar
Carter, L. J. (1976). Michigan's PBB incident: chemical mix-up leads to disaster. Science, N.Y. 192, 240.Google Scholar
Cattabeni, F., Cavallaro, A. & Galli, G. (1978). Dioxin: Toxicological and Chemical Aspects. New York: J. Wiley.Google Scholar
Clarkson, T. W., Amin-Zaki, L. & Al-Tikriti, S. K. (1976). An outbreak of methylmercury poisoning due to consumption of contaminated grain. Fedn. Proc. Fed., Am. Socs exp. Biol. 35, 23952399.Google Scholar
Crampton, R. F. & Charlesworth, F. A. (1975). Occurrence of natural toxins in food. Br. med. Bull. 31, 209213.CrossRefGoogle ScholarPubMed
Dent, J. G. (1978). Characteristics of Cytochrome P-450 and mixed function oxidase enzymes following treatment with PBB's. Environ Health Perspect. 23, 301307.CrossRefGoogle Scholar
Eisinger, J. (1978). Biochemistry and measurement of environmental lead intoxication. Q. Rev. Biophys. 10, 439466.CrossRefGoogle Scholar
Eisinger, J. & Blumberg, W. E. (1987). Unpublished observations.Google Scholar
Hites, R. A., LaFlamme, R. E. & Farrington, J. W. (1977) Sedimentary polycyclic aromatic hydrocarbons: The historical record. Science, N.Y. 198, 829831.Google Scholar
kristein, M. M., Arnold, C. B. & Wynder, E. L. (1977). Health economics and preventive care. Science, N.Y. 195, 457465.CrossRefGoogle ScholarPubMed
Langer, A. M. (1978). Crystal faces and cleavage planes in quartz as templates in biological processes. Q. Rev. Biophys. 10, 543576.CrossRefGoogle Scholar
Minamata Report (1969). In Minamata Disease (ed. Katsuma, M.). Kunamoto, Japan: Kunamoto University Press.Google Scholar
Niigata Report (1967). Report on the cases of mercury poisoning in Niigata. Ministry of Health and Welfare, Tokyo, Japan.Google Scholar
Poland, A. & Kende, A. (1976). 2,3,7,8-Tertachlorodibenzo–p–dioxin: environmental contaminant and molecular probe. Fedn. Proc. Fedn. Am. Socs. exp. Biol. 35, 24042411.Google Scholar
Pooley, F. D. (1979). Evaluation of fiber samples taken from the vicinity of two villages in Turkey. In Dust and Disease (ed. Demente, J. and Lemen, R.) Pathotox Pub. Co., (in press).Google Scholar
Report ON 2,4,5-T. A report on the panel of herbicides of the President's Scientific Advisory Committee. 03 1971. Washington, D.C., U.S. Government Printing Office.Google Scholar
Rodricks, J. V. (1978). Food Hazard of natural origin. Fedn. Proc. Fedn. Am. Socs. exp. Biol. 37, 25872593.Google ScholarPubMed
Selikoff, I. J. & Lee, D. H. K. (1978). Asbestos and Disease. New York: Academic Press.Google Scholar
Smith, R. J. (1978). Dioxins have been present since the advent of Fire, says Dow. Science, N.Y. 202, 11661167.CrossRefGoogle ScholarPubMed
Stoloff, L. (1977). Aflatoxins – an overview. In Mycotoxins in Human and Animal Health (ed. Rodricks, J. V., Hasseltine, C. W. and Mehlman, M.), pp. 728. Chicago: Pathotox Publishers Inc.Google Scholar
Wood, J. M., Fanchiang, Y-T. & Ridley, W. P. (1978). The biochemistry of toxic elements. Q. Rev. Biophys. 10, 467480.Google Scholar