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Bioprinting of three-dimensional culture models and organ-on-a-chip systems

Published online by Cambridge University Press:  10 August 2017

Yan Yan Shery Huang ,
Duo Zhang  and
Ye Liu
Yan Yan Shery Huang
Affiliation:
Department of Engineering, University of Cambridge, UK; yysh2cam@gmail.com
Duo Zhang
Affiliation:
Department of Engineering, University of Cambridge, UK; dz301@cam.ac.uk
Ye Liu
Affiliation:
Department of Engineering, University of Cambridge, UK; yl558@cam.ac.uk
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Abstract

Multimaterial bioprinting technologies offer promising avenues to create mini-organ models with enhanced tissue heterogeneity and complexity. This article focuses on the application of three-dimensional bioprinting to fabricate organ-on-a-chip systems for in vitro drug testing and screening. We illustrate the capabilities and limitations of a bioprinting approach compared to microfabrication in constructing an organ-on-a-chip device. Further, we propose strategies in multimaterial integration for printing microphysiological tissue models. With these analyses, key challenges and future directions are highlighted.

Keywords

biomedicaltissuefluidicsbiological synthesis (assembly)biomimetic (assembly)
Type
Research Article
Information
MRS Bulletin , Volume 42 , Issue 8: 3D Bioprinting of Organs , August 2017 , pp. 593 - 599
Copyright
Copyright © Materials Research Society 2017 

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