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Halloysite-Based Nanosystems for Biomedical Applications

Published online by Cambridge University Press:  01 January 2024

Francesca Persano ,
Giuseppe Gigli  and
Stefano Leporatti Open the ORCID record for Stefano Leporatti [Opens in a new window]
Francesca Persano
Affiliation:
Department of Mathematics and Physics, University of Salento, Via Per Arnesano, 73100, Lecce, Apulia, Italy CNR Nanotec-Istituto di Nanotecnologia, Via Monteroni, 73100, Lecce, Apulia, Italy
Giuseppe Gigli
Affiliation:
Department of Mathematics and Physics, University of Salento, Via Per Arnesano, 73100, Lecce, Apulia, Italy CNR Nanotec-Istituto di Nanotecnologia, Via Monteroni, 73100, Lecce, Apulia, Italy
Stefano Leporatti*
Affiliation:
CNR Nanotec-Istituto di Nanotecnologia, Via Monteroni, 73100, Lecce, Apulia, Italy
*
*E-mail address of corresponding author: stefano.leporatti@nanotec.cnr.it
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Abstract

Halloysite nanotubes (HNTs) are hollow clay nanotubes in the nanometer size range, made up of double-layered aluminum silicate mineral layers. HNTs represent an extremely versatile, safe, and biocompatible nanomaterial, used in a wide range of applications in biomedicine and nanomedicine. For example, they are used as transporters for the controlled release of drugs or genes, in tissue engineering, in the isolation of stem cells and cancer cells, and in bioimaging. Consequently, the assessment of the biocompatibility of HNTs has acquired considerable importance. In recent years, HNT composites have attracted attention due to their improved biocompatibility, compared to HNTs, suggesting potential for applications in tissue engineering or as vehicles for drugs or genes. In this review, recent advances in the application of HNTs and HNT composites in biomedicine are discussed to provide a valuable guide to scientists in the design and development of viable, functional bio-devices for biomedical applications.

Keywords

BiomedicineDrug deliveryGene DeliveryHalloysite Nanotube CompositesNanotubesTissue Engineering
Type
Review
Information
Clays and Clay Minerals , Volume 69 , Issue 5: Clay Minerals in Health Applications , October 2021 , pp. 501 - 521
Copyright
Copyright © The Clay Minerals Society 2021

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