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Brain Norepinephrine
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 (ISBN-13: 9780511271120)




Contents





  List of contributors page viii
  Acknowledgements xii
 
  Introduction: revision of an old transmitter 1
  Gregory A. Ordway, Ph.D.
 
Part I   The neurobiology of norepinephrine
1   Neuroanatomical and chemical organization of the locus coeruleus 9
  Kimberly L. Simpson, Ph.D. and Rick C. S. Lin, Ph.D.
2   Interactions of norepinephrine with other neurotransmitter systems: anatomical basis and pharmacology 53
  Craig A. Stockmeier, Ph.D. and Gregory A. Ordway, Ph.D.
3   Receptors for norepinephrine and signal transduction pathways 68
  David B. Bylund, Ph.D.
4   Regulation of gene transcription in the central nervous system by norepinephrine 95
  Ronald S. Duman, Ph.D. and Samuel S. Newton, Ph.D.
5   The norepinephrine transporter and regulation of synaptic transmission 119
  Subbu Apparsundaram, Ph.D.
 
Part II   Norepinephrine and behavior
6   Role of the locus coeruleus-norepinephrine system in arousal and circadian regulation of the sleep–wake cycle 157
  Gary S. Aston-Jones, Ph.D., Monica Gonzalez, and Scott Doran
7   The locus coeruleus and regulation of behavioral flexibility and attention: clinical implications 196
  Gary S. Aston-Jones, Ph.D., Michiyo Iba, Edwin Clayton, Janusz Rajkowski, and Jonathan Cohen
8   Norepinephrine and long-term memory function 236
  Benno Roozendaal Ph.D.
9   Norepinephrine and stress 275
  David A. Morilak, Ph.D.
 
Part III   The biology of norepinephrine in CNS pathology
10   Animal models of psychopathology: focus on norepinephrine
Leonie A. M. Welberg, Ph.D. Ph.D.and Paul M. Plotsky, Ph.D.
299
11   Neuropathology of central norepinephrine in psychiatric disorders: postmortem research 341
  Gregory A. Ordway, Ph.D.
12   Norepinephrine in mood disorders 363
  Pedro L. Delgado, M.D. and Cristinel Coconcea, M.D.
13   Noradrenergic pathology and pain 385
  Antti Pertovaara, M.D., Ph.D.
14   Norepinephrine and cognitive disorders 408
  Amy F. T. Arnsten, Ph.D.
15   Norepinephrine in neurological disorders 436
  Francesco Fornai, M.D., Ph.D.
16   Genetics of noradrenergic neurobiology 472
  Inna Belfer, M.D., Ph.D. and David Goldman, M.D.
 
Part IV   Psychopharmacology of norepinephrine
17   Actions of antidepressant and other drugs on norepinephrine systems 515
  Elliott Richelson, M.D.
18   The clinical role of norepinephrine antidepressants in depression and anxiety disorders 535
  J. Craig Nelson, M.D.
19   Norepinephrine in attention-deficit/hyperactivity disorder 557
  Fred W. Riemherr, M.D., Michael A. Schwartz, M.D., B. K. Marchant, and E. Higgins, M.D.
20   Psychopharmacology of norepinephrine in eating disorders 595
  Katherine A. Halmi, M.D. and Sun Young Yum
21   Role of norepinephrine in substance abuse 610
  Susan L. Broom, Ph.D. and Bryan K. Yamamoto, Ph.D.
  Index 628
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