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Hormones, Gender and the Aging Brain


  • 1 b/w illus. 11 tables
  • Page extent: 380 pages
  • Size: 244 x 170 mm
  • Weight: 0.61 kg


 (ISBN-13: 9780521041737)

The significance of hormone action in psychiatry has been long studied, now including the psychiatric effects of hormones on the aging process. This clinical reference addresses the hormonal basis of mental disorders in older people. Hormones influence a wide range of states and conditions, from pain tolerance and anorexia to attention, mood, immunity, cardiovascular and cognitive function, schizophrenia and Alzheimer's disease. Written by an eminent team of psychiatrists, psychologists, geriatricians and neuropharmacologists, this book brings together established information and findings in four sections: • An overview of the basic science of neurosteroids • Sex difference and the roles that cortisol, thyroid hormone, and the sex steroids estrogen, progesterone, dehydroepiandrosterone and testosterone play in common mental disorders and pain sensitivity • Psychoneuroimmunology in relation to age • Sex differences and hormones in psychotropic drug metabolism in the elderly.

• Unique coverage of the hormonal aspects and influences of mental disorders in the aging • Addresses the sex differences and how they affect mental disorders of the elderly • Introduced by an overview of the science and written by a cross-disciplinary team of eminent psychiatrists, psychologists, geriatricians and neuropharmacologists


List of contributors; Preface; Acknowledgements; Part I. Overview: 1. Summary chapter. The endocrine basis of geriatric psychiatry: an integrative approach John E. Morley; 2. Overview of steroids in the aging brain Loretta M. Flanagan-Cato; Part II. Hormones and Mental Health in the Elderly: 3. The hypothalamic-pituitary-adrenal axis in aging: preclinical and clinical studies John W. Kasckow, Thomas D. Geracioti Jr, Marta Pisarska, Ajit Regmi, Dewleen G. Baker and James J. Mulchahey; 4. The hypothalamic-pituitary-thyroid axis Gabriel K. Tsuboyama; 5. Estrogen and depression in aging women Mary F. Morrison and Kathryn Tweedy; 6. The role of testosterone in male depression Stuart N. Seidman and Steven P. Roose; 7. Dehydroepiandrosterone in aging and mental health Owen M. Wolkowitz, Patricia D. Kroboth, Victor I. Reus and Tanya J. Fabian; 8. Sex hormones, cognition and dementia in the elderly Kristine Yaffe; 9. Effects of estrogen on basal forebrain cholinergic neurons and cognition: implications for brain aging and dementia in women Robert B. Gibbs; 10. Gender and schizophrenia Laurie A. Lindamer, M. Jackuelyn Harris, Julie Akiko Gladsjo, Robert Heaton, Jane S.Paulsen, Shelley C. Heaton and Dilip V. Jeste; 11. Sex steroids and anxiety disorders Teresa A. Pigott; 12. Gender and hormonal factors in pain and pain inhibition Wendy F. Sternberg; Part III. Effects of Hormones and Behavior on Immune Function: 13. Estrogens, stress and psychoneuroimmunology in women over the lifespan Mary H. Burleson, Susan Robinson-Whelan, Ronald Glaser and Janice K. Kiecolt-Glaser; 14. Gender differences in immune function at the cellular level Eva Redei and Suresh G. Shelat; Part IV. Hormones and Gender Differences in Psychotropic Drug Metabolism: 15. Gender differences in psychotropic drug metabolism Bruce G. Pollock; 16. The influence of progesterone on the pharmacokinetics and pharmacodynamics of gamma-aminobutyric acid-active drugs Patricia D. Kroboth and James W. McAuley; Index.


'This reference text provides an excellent and comprehensive overview of the role of hormones (primarily steroid hormones, such as estrogens, androgens, glucocorticoids and thyroid hormones) in the aging brain and in relationship to mental health in the elderly … an excellent review of current knowledge in endocrinology related to geriatric psychiatry.' Deborah R. Gustafson, Acta Psychiatrica

'… an engaging read for those working on old age psychiatry … it brings things together clearly and offers a stimulating and enjoyable read'. Susan M. Benbow, International Geriatric Psychiatry

'… provides valuable information for clinicians and basic researchers alike in this complex and growing area.' Glenda Gillies, Journal of Neurological & Neurosurgical Psychiatry

'… clear, well presented … it offers plenty of ideas for future research in the area of endocrinology and psychiatry …' Bebe Fahy, International Journal of Geriatric Psychiatry


John E. Morley, Loretta M. Flanagan-Cato, John W. Kasckow, Thomas D. Geracioti Jr, Marta Pisarska, Ajit Regmi, Dewleen G. Baker, James J. Mulchahey, Gabriel K. Tsuboyama, Mary F. Morrison, Kathryn Tweedy, Stuart N. Seidman, Steven P. Roose, Owen M. Wolkowitz, Patricia D. Kroboth, Victor I. Reus, Tanya J. Fabian, Kristine Yaffe, Robert B. Gibbs, Laurie A. Lindamer, M. Jackuelyn Harris, Julie Akiko Gladsjo, Robert Heaton, Jane S. Paulsen, Shelley C. Heaton, Dilip V. Jeste, Teresa A. Pigott, Wendy F. Sternberg, Mary H. Burleson, Susan Robinson-Whelan, Ronald Glaser, Janice K. Kiecolt-Glaser, Eva Redei, Suresh G. Shelat, Bruce G. Pollock, James W. McAuley

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